Metal mediated bilirubin encephalopathy: Treatment with D-Penicillamine

Introduction Our recently published case reports and other healthy and highly educated patients of the long-term (28-42 years) follow-up suggest that D-Penicillamine (D-PA) therapy of newborn infants may have significant neuroprotective effects in cases jeopardized by bilirubin induced neurologic dysfunction (BIND) or retinopathy of prematurity (ROP) [1-3]. The first patient (43 ys) is now a member of a famous operahouse in Germany as an opera singer, the second one (16 ys) is excellent in music and matematics. In addition, it was our privilage to follow a number of children who are now adults, including sons and daughters of our relatives, colleaques, close friends. They are now highly educated persons working in health care (mostly as physicians), bank, computer and building industry, et cet.